摘要
目的探讨血脂变化及胰岛素抵抗与2型糖尿病肾病病变程度的关系。方法根据尿清蛋白肌酐比(ACR)将190例2型糖尿病(DM)患者分为单纯DM组、早期糖尿病肾病(DN)组、临床DN组、晚期DN组,分别测定各组患者的尿清蛋白肌酐比、血脂、空腹血糖(FBG)、糖化血红蛋白(HbAlC)、空腹胰岛素(FINS)水平。结果(1)与无糖尿病肾病组比较,DN各组甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白B(ApoB)明显升高(P<0.05),高密度脂蛋白胆固醇(HDL-C)、载脂蛋白A(ApoA)、胰岛素敏感指数(ISI)明显降低(P<0.05)。(2)ACR与TC(r=0.285,P<0.01)、LDL-C(r=0.321,P<0.01)、ApoB(r=0.345,P<0.01)呈正相关,与HDL-C(r=-0.378,P<0.01)、ApoA(r=-0.268,P<0.01)、ISI(r=-0.305,P<0.01)呈负相关。结论脂代谢紊乱及胰岛素抵抗(IR)可能与2型DN有一定的相关性。
Objective To investigate the relation between type 2 diabetic nephropathy and blood lipid levels with insulin resistance. Methods The study included 50 patients with type 2 diabetes mellitus without nephropathy, 45 patients with early stage diabetic nephropathy,52 patients with diabetic nephropathy and overt proteinuria, 43 patients with end- stage diabetic nephropathy. Serum level of their lipid, blood sugar, HbA 1 c, insulin , and albumin -to -creatinine ratio （ACR）were monitored. Results （ 1 ）The lever of serum TG. TC .LDL -C. ApoB were increased in the three groups of diabetic nephropathy , there was significant difference between the group of diabetes mellitus without nephropathy and the three groups with diabetic nephropathy （P 〈 O. 05） ; the levers of serum HDL -C , APo -A, ISI were decreased in the three groups of diabetic nephropathy ,there was significant difference between the group of diabetes mellitus with- out nephropathy and the three groups with diabetic nephropathy （ P 〈 0.05 ）. （ 2 ） ACR was positively correlated with TC （ r = 0. 285 P 〈 0.01）,LDL-C（r=0.321 P〈0.01） ,ApoB（r=0.345 P〈0.01）;ACR was negatively correlated with HDL-C（r = -0.378 P〈 O. O1 ） , ApoA （r = - 0. 268 P 〈 0.01 ） ,ISI（ r = - 0. 305 P 〈 0.01 ）. Conclusions Disorder of lipid metabolism and insulin resistance may be related with type 2 diabetic nephropathy.
出处
《医学研究杂志》
2007年第7期79-80,共2页
Journal of Medical Research
关键词
2型糖尿病
糖尿病肾病
血脂
2 Diabetic
Diabetic nephropathy
Blood lipid
