摘要
目的观察唑来膦酸联合放疗治疗骨转移癌的疗效。方法将60例骨转移癌患者随机分为观察组(30例)和对照组(30例)。观察组静脉点滴唑来膦酸4mg加局部放疗30Gy/10f/2w,对照组则单纯行放疗。结果观察组与对照组疼痛总缓解率分别为93.3%和73.3%,有显著性差异(P<0.05)。观察组和对照组KPS评分改善有效率分别为90.0%和66.7%,两组差异有显著性差异(P<0.05)。结论唑来膦酸联合放疗治疗骨转移癌疼痛疗效优于单纯放疗,明显提高患者生存质量。
Objective To evaluate the efficacy of zoledronic acid combined with radiotherapy for bone metastatic cancer. Methods 60 cases with bone metastatic cancer were randomized into observation group （30 cases ） and control group （30cases）. The observation group was treated with zoledronic acid,4 mg introveniously and local radiotherapy with a total dose of 30 Gy in 10 fraction in 2 weeks. The control group was treated by radiotherapy alone. Results Pain relief was noted in 93.3% patients in the observation group and 73.3% patients in the control group,respectively. The difference between the two groups was significant（ P 〈0.05 ）. The scale improvement,as evaluated by Karnofsky scale,was noted in 90.0 % patients in the observation group and 66.7% patients in the control group, respectively. The difference was also statistically significant（ P 〈 0.05 ）. Conclusion Zoledronic acid combined with radiotherapy was superior to radiotherapy alone for metastatic cancer bone pain relief and quality of life improvement.
出处
《实用癌症杂志》
2007年第4期404-406,共3页
The Practical Journal of Cancer
关键词
唑来膦酸
放疗
骨转移癌
Zoledronic acid
Radiotherapy
Bone metastatic cancer
