摘要
生物碱加兰它敏为可逆性乙酰胆碱酯酶(AChE)的抑制剂,对阿尔海默氏老年痴呆症有较好的疗效,介绍了以K3[Fe(CN)6]、钯络化物、三价碘化物等为氧化剂的氧化关环方法合成加兰它敏的方法,并总结了各种其外消旋体的拆分方法,简要评价了各种方法的优缺点。
The natural alkaloid galanthamine which acts as a inhibitor of acetylcholine esterase, is a new drug for curing Alzheimer＇s disease. The synthesis methods of galanthamine via phenolic coupling step using K3 [Fe（CN）6], palladium-complex and iodine （ Ⅲ ） reagent as oxidant were introduced, and racemic resolution methods for galanthamine were summarized. Findlly, their advantage and disadvantage of synthetic and resolutions methods of galanthamine were put forwarded.
出处
《精细化工中间体》
CAS
2007年第2期13-16,24,共5页
Fine Chemical Intermediates
关键词
加兰它敏
阿尔海默氏
乙酰胆碱酯酶抑制剂
galanthamine
Alzheimer＇s disease
acetylcholinesterse inhibitor （ACHE）
