摘要
分析了不同烧伤程度大鼠肝、脾、肾和骨骼肌内４种急性期蛋白（ＡＰＲ），即α１－酸性糖蛋白（ＡＧＰ）、α１－抗胰蛋白酶（ＡＴ）、白蛋白（Ａｌｂ）和转铁蛋白（Ｔｒｆ）ｍＲＮＡ水平的动态变化特征，结果表明：①肝脏是合成各种ＡＰＲ的主要场所；②即使是小面积的烧伤也可以诱发急性期反应，除了Ｔｒｆ外，其余ＡＰＲｍＲＮＡ的表达水平随着烧伤程度的增加而增加；③烧伤后血清Ａｌｂ水平下降是急性期反应的特征，但在ｍＲＮＡ水平上并不下降而是增加。
The dynamic changes in the levels of acute phase reactant(APR) mRNA in different tissue of rats receiving a 10% or 60% TBSA fullthickness burn were studied.The results of the study indicated that (1) the major site of APR synthesis was the liver;(2) even a small surface burn injury could elicit a rapid acute phase response,but the intensity of APR mRNA expression increased with the severity of the burn.(3) the down regulation of albumin mRNA,which was characteristic of the acute phase response,did not occur even though transfterrin (Trf) mRNA levels were significantly decreased.
出处
《解放军医学杂志》
CAS
CSCD
北大核心
1997年第1期46-48,共3页
Medical Journal of Chinese People's Liberation Army
