摘要
作者通过对清醒无拘束豚鼠对组胺、乙酰胆碱和抗原气道反应性的研究，发现有以下特点：呼吸变化在24h连续可测；吸入组胺（His）和乙酰胆碱（ACh）后的引喘作用有浓度依赖性，半数有效引喘浓度（EC50）分别为53．3μmol／m3和269μmol／m3；对His的反应有昼夜节律性；致敏豚鼠吸入抗原可以诱发哮喘反应，在30min内最明显，吸抗原后6h对ACh的反应性增强。
In the conscious and unrestrained guinea pigs, we found the following characteristics: (1)The response to histamine(His) or acetylcholine (ACh) aerosol was concentration-dependent on EC50(the effective concentration that causes 50% animals to wheeze)of 53. 3μmol/m3,and 269μmol/m3 respectively. (2)Antigen (OA) induced a lasting wheezing for about 30 min,and the response to ACh increased after inhalation of antigen in the sensitized guinea pigs. (3) The response to His aerosol showed a circadian variation.
基金
国家自然科学基金!39270789
关键词
气道阻力
哮喘
病因学
Airway resistance
Histamine
Acetylcholine
Guinea pigs
Asthma/etiol
