摘要
采用人结肠癌裸鼠腹腔种植瘤模型，进行表阿霉素早期和延期腹腔内化疗，观察其对癌细胞腹腔内种植的影响。15只雄性裸鼠腹腔内接种Lovo细胞后，随机分成对照组、早期和延期腹腔内化疗3组。早期腹腔内化疗组以0．8mg/kg/d表阿霉素于接种后1～3天行腹腔注射，延期组用相同剂量于接种后5～7天行腹腔注射。结果显示，早期腹腔内化疗组裸鼠平均荷瘤生存时间最长；延期腹腔内化疗组次之；对照组最短。前者与后两者比较，均有显著性差异（P＜0．05和P＜0．01）。实验提示早期腹腔内化疗的抑瘤作用明显高于延期腹腔内化疗。
Early and delayed intraperitoneal administration of anticancer agents were carried out in nude mice implanted intraperitoneally with human colonic cancer cells. Lovo cell suspension was given to 15 athymic BALB/c (nu/nu) nude mice intraperitoneally. All the mice were randomized into three groups: 1)control group, 2)early group injected with 0. 8mg/kg/d of epirubicin on the 1-3rd day after inoculation, 3)delayed group recieved the same dose of epirublcin on the 5-7th day.The results showed that the longest mean survival time was achieved in the early group,medium survival period was observed in the delayed group,and the shortest in the control group. A significant difference exists between the early and the delayed groups (P<0. 05 ),as well as between the early and the control groups (P<0. 01). This study lndicates that early admlnistration of anticancer agents rendersmore remarkable inhibition of intraperitoneal implantation of tumor cells.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
1997年第3期210-213,共4页
Chinese Journal of Clinical Oncology
关键词
结肠肿瘤
药物疗法
腹腔内
表阿霉素
Intraperitoneal administration Epirubicin Colonic tumor cell line Peritoneal implantation
