摘要
为探讨强的松龙治疗颞下颌关节紊乱综合征的机理，对１２只家兔进行了研究。首先在家兔右侧颞下颌关节腔内注射肿瘤坏死因子（ｔｕｍｏｒｎｅｃｒｏｓｉｓｆａｃｔｏｒ，ＴＮＦ）２～３次，９．０万ｕ／次；再注射强的松龙１～２次，２ｍｇ／次，光镜检查。结果：本组动物的关节组织损害明显减轻，关节软骨只有表面层轻微的改变或接近正常。结论：强的松龙能够抑制ＴＮＦ对兔颞下颌关节组织的损害，这可能是临床上糖皮质激素治疗颞下颌关节紊乱综合征有效的原因之一。
In order to study the mechanism of hydroprednisolone for temporomandibular joint disturbance syndrome (TMJDS), 12 white rabbits were injected TNF into the rabbits' right TMJDS for 2 to 3 times, 90 000 u each time, then another drug, 2mg hydroprednisolone, was injected into these TMJDS again. The rabbits were killed after 8 to 18 days and the TMJDS were examined by microscope. We found the articular tissues only destroyed slightly and sometimes the cartilages were nearly normal. So, the study suggested that hydroprednisolone can reduce the destruction of TNF on rabbit's TMJ obviously. This may be the cause why hydroprednisolone is useful to TMJDS.
出处
《中华口腔医学杂志》
CAS
CSCD
北大核心
1997年第2期89-91,共3页
Chinese Journal of Stomatology
基金
浙江省卫生厅课题基金
关键词
颞下颌关节紊乱
综合征
糖皮质激素
药物疗法
Temporomandibular joint disturbance syndrome Tumor necrosis factor Glucocorticoids Histological techniques
