摘要
应用给豚鼠注射硫酸锌的方法，观察了锌对豚鼠卡那霉素中毒性耳聋的影响。通过观察给药组和对照组动物的耳廊反射（ＰＲ）阈，脑干听觉诱发电位（ＢＡＥＰｓ）阈变化及耳蜗底回外毛细胞缺失率，发现硫酸锌注射组和对照组豚鼠的４、６、８ＫＨｚＰＲ阈在处死时分别升高１４．５６±３．１２ｄＢ，１５．８８±３．３８ｄＢ，１８．１２±２．７０ｄＢ和１７．１２±３．５６ｄＢ，１６．１５±２．５８ｄＢ，１９．２５±３．０１ｄＢ（Ｐ＞０．０５）。
The effects of zinc on kanamycin ototoxicity in guinea pigs were observed by injecting zinc sulphate into the abdominal cavity of guinea pigs.The Preyer's reflex(PR)threshold,brainstem auditory evoked potentials (BAEPs)threshold and the absent rate of outer hair cells in the basal coil of cochlea were compared between the control and experimental groups.The PR thresholds of 4,6,8 KHz on 13th day in control and experimental groups were increased by 14 56±3 12 dB,15 88±3 38 dB,18 12±2 70 dB and 17 12±3 56 dB,16 15±2 58 dB,19 25±3 01 dB respectively.The results suggested that injecting zinc sulphate into abdominal cavity had no effects on kanamycin ototoxicty in guinea pigs.
出处
《微量元素与健康研究》
CAS
1997年第1期9-10,共2页
Studies of Trace Elements and Health
关键词
卡那霉素
中毒性耳聋
锌
BAEPs
硫酸锌
Guinea pigs
Brainstem auditory evoked potentials
Preyer's refles
Kanamycin
Zinc sulphate
