摘要
人类白细胞抗原E(HLA-E)属于非经典人类主要组织相容性复合体(MHC-Ib)类分子,是继HLA-A、B、C之后人类发现的第4个MHC-I类分子,相比较MHC-Ia类分子,具有有限的多态性,广泛的组织分布和低水平的细胞表面表达等特点,在母胎免疫耐受、移植免疫、抗肿瘤和抗病毒免疫中的作用引起人们高度重视。
Human histoeompatibility leukocyte antigen（HLA）-E is a nonclassical major histocompatibility complex （MHC）class I molecule,which is the 4th major histocompatibility complex （MHC）class I molecule that human have found following up that of HLA-A ,B,C. HLA-E is distinguished from the classical MHC class I molecule by limited allelic polymorphism,low expression on the cell surface and extensive tissue distribution.Human have paid great attention to the important role of HLA-E that it plays in maternal-placental immunological tolerance, transplantation immunization, as well as antitumor and antiviral immunity.
出处
《医学综述》
2007年第12期881-883,共3页
Medical Recapitulate
基金
国家自然基金资助项目(30570977)
教育部科学技术研究重点资助项目(206031)
