摘要
目的:观察格列美脲、二甲双胍治疗代谢综合征(MS)的疗效。方法:将68例代谢综合征患者随机分成两组,分别采用格列美脲、二甲双胍治疗。观察两组治疗前后空腹血糖(FBG)、餐后血糖(PBG)、糖化血红蛋白(HbA1C)、甘油三脂(TG)、空腹胰岛素(FIn)、体重指数(BMI)的变化。结果:两组治疗后FBG、PBG、HbA1C、FIn均较治疗前下降(P<0.01),但格列美脲组FIn下降程度高于二甲双胍组(P<0.01)。两组治疗后TG及BMI均较治疗前下降(P<0.01)。结论:格列美脲和二甲双胍均能改善代谢综合征患者的糖代谢、脂代谢,而格列美脲改善胰岛素抵抗,增加胰岛素敏感性较二甲双胍作用强。
Objective：To evaluate the effect of glimepiride and metformin therapy on metabolic syndrome（MS）. Methods：Sixty-eight patients with MS were randomly assigned to receive glimepiride or metformin. The fasting blood glucose （ FBG ）, postprandial blood glucose （ PBG ） , glycosylated hemoglobin （ HbA1C ） , triglycerides （ TG ） , fasting insulin levels （ Fin ） and the values of body mass index （BMI） of the two groups were compared before and after treatment. Results： FBG, PBG, HbA1C and Fin decreased significantly in the two groups （ P 〈 0. 01 ）, but Fin decreased more obviously in the glimepiride group （ P 〈 0.01 ）. TG level and BMI decreased significantly in the two groups （ P 〈 0.01 ）. Conclusions ： Both glimepiride and metformin can improve the glucose metabolism and lipid metabolism. Glimepiride is more effective than metformine in improveing IR and insulin sensitiviry.
出处
《蚌埠医学院学报》
CAS
2007年第4期445-446,共2页
Journal of Bengbu Medical College
关键词
代谢病
格列美脲
二甲双胍
metabolic diseases
glimepiride
metformin
