摘要
目的探讨经肝动脉化疗栓塞(TACE)对高危因素肝癌的治疗效果。方法回顾性分析2001年1月至2005年12月266例肝癌患者接受536次介入治疗,患有门静脉癌栓或血胆红素升高(>34μmol/L)者为高危组,余患者为低危组。高危组74例(27.8%),低危组192例。高危组采用更加超选择性栓塞、较少的栓塞剂用量和较少的手术次数(为1.4和2.3P<0.05),比较两组患者的术后并发症发生率、生存期。结果全部并发症的发生率为3.5%,两组并发症的发生率差异无统计学意义(分别为2.5和7.6%,P=0.07),高危组1、3年生存率分别为45%和16%,低危组1、3年生存率分别为63%和18%,低危组生存期长于高危组,但两组间差异无统计学意义(P=0.08)。结论高危因素肝癌患者TACE术后并发症发生率未显著增加。采用适当的技术,TACE对高危因素肝癌患者是安全的。
Objective To explore the therapeutic efficacy of transcatheter arterial chemoembolization （TACE） for liver cancer with high-risk factors. Methods A retrospective analysis of all patients undergoing TACE for liver cancer in our hospital from January 2001 to December 2005 was performed. 266 patients with liver cancer underwent 536 TACE procedures, seventy-four patients （27.8%） designated in the high-risk group, as a result of major portal vein thrombosis, and increased serum bilirubin （ 〉 2 mg/dl） ; the others were in the low-risk group. High-risk patients received more superseleetive embolization with lower dose of embolization agent and fewer numbers of procedure （1.4 vs 2.3, P 〈 0.05）. The comparasion was taken between the two groups on the topics of the postoperative complication and survival rates. Results The overall complication rate was 3.5% with no significant statistical difference in complication rates between the two groups （2.5 vs 7.6%, P = 0.07）.The 1 and 3 year survival rates were 45% and 16%, in high-risk group and 63% and 18% in low-risk groups respectively. A trend towards increase of survival in the low-risk group, but with no statistical significance between the two groups （P = 0.08）. Conclusions High-risk patients undergoing TACE have no significant increase in complication rate. Using rather proper technique, TACE can be performed safely in patients with high-risk factors. （J Intervent Radiol, 2007, 16： 378-380）
出处
《介入放射学杂志》
CSCD
2007年第6期378-380,共3页
Journal of Interventional Radiology
关键词
肝动脉化疗栓塞
肝癌
高危因素
生存
Transarterial chemoembolization
Liver cancer
High-risk
Survival
