摘要
目的讨论氩氦刀联合放化疗治疗局部晚期非小细胞肺癌的疗效。方法2003年10月至2006年2月采用氩氦刀联合放化疗治疗局部晚期非小细胞肺癌42例(综合组),选择同期条件相同采用常规放化疗局部晚期非小细胞肺癌38例作对照(常规组);比较两组病人的KPS、局部复发率、中位生存期、生存率。结果综合组和常规组的KPS改善率分别为28.57%和10.52%,稳定率分别为42.86%和36.84%,恶化率分别为28.57%和52.63%;综合组KPS评分高于常规组(χ2=6.32,P<0.05)。原发灶局部复发率综合组显著低于常规组(28.57%<50.00%;χ2=3.86,P<0.05);中位生存期综合组16个月,常规组14个月;1、2、3年生存率综合组稍高于常规组(63.53%>53.50%,31.99%>29.13%,21.33%>16.18%)。但两组间生存曲线比较无统计学意义(χ2=0.33,P<0.05)。结论氩氦刀联合放化疗可有效地降低不可切除非小细胞肺癌的局部复发率,改善病人功能状态。
Objective To evaluate the efficacy of combined cryosurgery and chemoradiotherapy, performed by using cryocare surgical system, for treatment of inoperable non-small cell lung cancer. Methods Forty-two patients with locally advanced non-small cell lung cancer （combination group ） were treated by combination of chcmoradiotherapy and percutaneous cryosurgery from Oct,2003 to Feb .2006. The efficacy was compared with that of 38 patients who received conventional chemotherapy or radiotherapy （conventional group ）in the same period, Results KPS for patients in the synthetic group was superior to that patient in the conventional group （X^2 = 6.32 ,P〈0.05 ）, The local recurrent rate in the combination group was less than that in conventional group （28.57 % 〈50.00 %; X^2 = 3.86,P〈0.05）, Median survival time was 16 months in the combination group and 14 months in the conventional group. There was better one-year, two-year, three-year survival rates for the combination group compared with the conventional group （63.53 % 〉53.50% , 31,99% 〉29.13 % , 21,33% 〉16.18%）,but without statistically differences. （X^2=0.33,P〉0.05）. Conclusion Combined chemoradiotherapy and percutaneous cryosurgery by using cryocare surgical system can decrease local recurrence and improve performance status for locally advanced non-small cell lung cancer,
出处
《中国疗养医学》
2007年第7期391-393,共3页
Chinese Journal of Convalescent Medicine
关键词
局部晚期非小细胞肺癌
氩氯刀
综合治疗
Locally advanced non-small cell lung cancer
Chemoradiotherapy
Cryosurgery
