摘要
目的:观察不同国产止吐药预防头颈部癌含顺铂(cisplatin,DDP)方案化疗引起的恶心、呕吐的临床疗效和不良反应。方法:63例患者采用含DDP方案化疗90周期,随机分为3组,各化疗30周期,分别给予国产恩丹西酮(欧贝)、格拉司琼(琼沙奥或君凯)、托烷司琼(赛格恩)预防恶心、呕吐反应。结果:防治恶心、呕吐的有效率格拉司琼组为93.3%,托烷司琼组为86.7%,恩丹西酮组为83.3%,3组之间疗效比较差异无显著性;3种止吐药毒副反应相似,以便秘、倦怠及头痛多见,但程度较轻。结论:国产恩丹西酮、格拉司琼、托烷司琼均为头颈部癌含DDP方案化疗的有效止吐药,其疗效相似,不良反应轻,病人可耐受。
Objective ： To evaluate the clinical efficacy and adverse effects of three 5-HT3 antagonists （granisetron, tropisetron, and ondansetron that produced in china） for the prevention of cisplatin-induced nausea and emesis in patients with head and neck cancers. Methods： Sixty-three patients that treated with high dose （80 - 100 mg/m^2） of cisplatin for 90 cycles following chemotherapeutic regimens were ramdomly divided into three groups to receive antiemetic drugs including granisetron, tropisetron, and ondansetron. Results： The efficacy rates of granisetron, tropisetron, and ondansetron were 93.3%, 86.7%, and 83.3% respectively （P 〉0.05）. Their side-effects were similar which were frequent constipation, fatigue and headache, but were mild and bearable. Conclusions： granisetron, tropisetron, and ondansetron are effective drugs in prevention of cisplatin-induced emesis in patients with head and neck cancers.
出处
《贵阳医学院学报》
CAS
2007年第3期264-266,共3页
Journal of Guiyang Medical College
基金
贵州省省长基金资助项目
关键词
呕吐
恶心
抗肿瘤联合化疗方案
格拉司琼
托烷司琼
恩丹西酮
vomiting
nausea
antineoplastic combined chemotherapy protocols
granisetron
tropisetron
ondansetron
