摘要
应用脑内微透析技术观察五菟颗粒剂在大鼠脑缺血时海马细胞外液氨基酸的变化。结果显示：该药对缺血前脑细胞外液氨基酸水平无明显影响（Ｐ＞０．０５）；缺血时，试验组Ｇｌｕ和Ａｓｐ比对照组明显减低（Ｐ＜０．０１）。提示当脑缺血时，五菟颗粒剂能减少脑细胞兴奋性氨基酸的释放，对脑组织起保护作用。
We observed the changes of excitatory amino acids (EAA) in extracellular fluid (ECLF) in rat hippocampus in case of cerebral ischemia after giving Wuto Granule compring the test groups with the control groups by microdialysis method. Results showed that there was no effect on EAA in extrcellular fluid by the drug before cerebral ischemia, but there existed staistical singnifcant changes of EAA in extracellular fluid one hour after cerebral ischemia comparing the test groups Glu and Asp with the control groups (P<0.01). We found that there is a decrease of release of release of EAA in ECLF in case of ischemia by W uto Granule. It could be deduced that Wuto Granule can penetrate the brain blood barrier and this can protect the brain incse of ischemia. The application of intracerebral micrdialysis has provided a new method for the research work of pharmocology.
出处
《湖南医科大学学报》
CSCD
1997年第1期19-21,共3页
Bulletin of Hunan Medical University
