摘要
目的：探讨影响中药贴敷剂（ＣＴＣＭ）主要制备工艺条件，并对ＣＴＣＭ进行质量检查。方法：采用均匀设计方法，对粘合剂、无机盐、充填剂、乳化剂、保湿剂、乙烯聚合物进行Ｕ７（７６）的实验，得出最优配比组成，对ＣＴＣＭ做初粘性、持粘性、粘着力、耐寒、耐热、粘敷性、刺激性及致敏性试验。结果：ＣＴＣＭ具有载药量大，贴敷性能好，稳定性高，无致敏性与刺激性。基质适用性广，可与任何中药提取物配合，制备工艺简单，可直接采用硬膏涂布机进行生产，降低了工艺中涂布烘干温度，减少中药有效成分的分解及挥发性成分的挥散，明显提高皮肤给药的治疗效果。结论：ＣＴＣＭ符合临床使用的要求。
OBJECTIVES:To investigate the preparing technicues,factors affecting the main characteristics of cataplamat of traditional Chinese medicine(CTCM),and to determine CTCM quality.METHODS:Using homogeneous design optimum seeking method,we obtained the optimal preparing conditions through experiment on six factors:adhesive(A),inorganic salt(B),filling agent(C),emulsifier(D),maintainable mosit agent(E),vingl polymer(F).Mass analyzsis of CTCM prepared according to these conditions was made,such as viscosity for the firstime/continued viscosity/adhesion/cold resistantce/heat resistance/adhesion/irritation tests.RESULTS:The volume of drug in CTCM was large,the adhesion appropriate,the adhesiveness better.The stability was higher.No sensitization and irritation.The substrates could coordinate any extracts of traditional Chinese medicine.CONCLUSION:CTCM prepared in our laboratory corresponds with clinical use,and could be used as a new plaster.
出处
《中国药学杂志》
CAS
CSCD
北大核心
1997年第3期145-147,共3页
Chinese Pharmaceutical Journal
基金
全军"八五"青年基金
关键词
中药贴敷剂
均匀设计法
homogeneous design method,cataplamat of traditional Chinese medicine,preparing techniques
