摘要
采用免疫组化技术和银染色技术对31例肾孟癌及9例慢性肾盂炎症组织中增殖细胞核抗原（PCNA）、核仁组成区嗜银蛋白（AgNOR）进行研究。结果发现肾盂癌PCNA增殖指数和AgNOR颗粒计数显著高于炎症组，且与肿瘤病理分级、临床分期及预后有关；肾盂癌PCNA增殖指数与AgNOR计数间存在显著正相关性；还发现PCNA增殖指数＞75％者术后易再发膀胱肿瘤。提示PCNA免疫染色和AgNOR计数在鉴别肾盂良恶性病变和判断肾盂癌生物学行为方面具有重要意义。
Proliferating cell nuclear antigen (PCNA) and nucleolar organizer region associated protein (AgNOR) were investigated in 31 cases of carcinoma of renal pelvis and 9 cases of chronic pyelitis tissue using the immunohistochemical and silver colloid technique. The result showed thatPCNA index and AgNOR counts were higher in tumor tissue than that in pyelitis tissue and were related to tumor grade, stage or prognosis. There was a significant correlation between PCNA index and AgNOR counts. Tumors with the PCNA index more than 75 percent were predisposed to the occurrence of bladder tumor after operation for renal pelvis cancer. Our findings suggested that PCNA and AgNOR might be of value in the differentiation of benign and malignant renal pelvis lesions and in the evaluation of the biological behavior of renal pelvis cancer.
出处
《临床泌尿外科杂志》
1997年第1期39-41,共3页
Journal of Clinical Urology
关键词
肾盂肿瘤
AGNOR染色
免疫组织化学
PCNA
Carcinoma of renal pelvis Proliferating cell nuclear antigen AgNOR Immunohistochemical technique Silver colloid technique
