摘要
目的:面对日益复杂的抗癫痫药应用状况,对传统及新型抗癫痫药的临床应用状况进行评价以期为临床合理用药提供参考。方法:从6个传统抗癫痫药和9个新型抗癫痫药的临床适应证及其药动学特点、不良反应和药物相互作用,患者的年龄、性别和疾病状态以及经济因素等方面对影响抗癫痫药合理选择的因素作一探讨。结果及结论:传统抗癫痫药仍被广泛应用,新型抗癫痫药与传统抗癫痫药相比具有药代动力学更好、药物相互作用更少、耐受性更好等优势,但临床资料和用药经验相对缺乏,临床应用时应权衡利弊,合理选择。
OBJECTIVE ： In view of the increasingly complicated situation in the use of antiepileptic drugs, this paper is to evaluate the clinical application of the traditional antiepileptic drugs and the neotype antiepileptic drugs so as to provide reference for their rational use in the clinic. METHODS： The factors influencing the choice of antiepileptics, including indication, pharmacokinetics, adverse reactions, interactions of drugs, patients＇ age, gender, morbid state and economic factors etc. of 6 traditional antiepileptics and 9 neotype antiepileptics were discussed. RESULTS ＆ CONCLUSION： The traditional antiepileptics were still be used widely; the neotype antiepileptic drugs have the competitive edges over the traditional ones for which have a better pharmaeokinetics, less drug interactions, better tolerance, yet there is lack of clinical data and medication experience of neotype ones, therefore, both the merits and demerits should be weighted so as to make a rational choice between the two in their clinical use.
出处
《中国医院用药评价与分析》
2007年第3期183-187,共5页
Evaluation and Analysis of Drug-use in Hospitals of China
关键词
传统抗癫痫药
新型抗癫痫药
合理选择
Traditional antiepileptic drugs
Neotype antiepileptic drugs
Rational choice
