摘要
吗啡依赖大鼠自发戒断后其主动接触时间（群居接触实验）和冲突期舔水次数（Ｖｏｇｅｌ冲突模型）均显著减少，并可被５－ＨＴ１Ａ受体激动剂丁螺环酮和色氨酸羟化酶抑制剂对氯苯丙氨酸（ＰＣＰＡ）所对抗。纳曲酮（ＮＴＸ）也可使上述两指标降低，并可被吗啡和ＰＣＰＡ所拮抗、被５－羟色氨酸所增强。吗啡戒断和ＮＴＸ均可使高钾诱发的缝核区脑片５－ＨＴ释放增多。结果提示，吗啡戒断或ＮＴＸ均可产生焦虑；这可能是由于中枢阿片能神经对５－ＨＴ能神经的紧张性抑制作用发生紊乱或受阻。
The spontaneous withdrawal from morphine in morphine dependent rats significantly decreased the duration of active interaction in social interaction test and the number of licks during the shock punished period in Vogels conflict procedure, which were attenuated by buspirone, a 5 HT 1A agonist, as well as para chlorophenylalanine (PCPA) , an inhibitor of tryptophan hydroxylase. Naltrexone (NTX), a potent opioid receptor antagonist, also dose and time dependently reduced both indices mentioned above, which was blocked by morphine or PCPA and was enhanced by 5 hydroxytryptophan, a precursor of 5 HT. In the test of neurotransmitter releases in rat brain slices, both morphine withdrawal and NTX enhanced high potassium(30mM) induced 5 HT release in slices of the area of the raphe nucleus. These results suggested that both morphine withdrawal and NTX produced anxieties in morphine dependent and normal rats,respectively,which were mediated by the central 5 HTergic neurotransmission.Central opioidergic neurons inhibited 5 HTergic neurons tonically and presynaptically. Such an effect was reduced or blocked by NTX, or during morphine withdrawal,and 5 HT ergic neurons were disinhibited, leading to a state of anxiety.
出处
《生理科学进展》
CAS
CSCD
北大核心
1997年第1期41-44,共4页
Progress in Physiological Sciences
关键词
吗啡
纳曲酮
药理学
焦虑
中枢
神经调控
Anxiety
Animal model
Morphine
Withdrawal symptoms
Naltrexone
