摘要
目的研究VIP对大鼠Leydig细胞FasL表达及介导Jurkat细胞凋亡的影响。方法VIP作用于UU感染的SD大鼠及大鼠Leydig细胞,观察VIP对大鼠Leydig细胞FasL表达的调节,从体外及动物整体水平来探讨VIP对大鼠Leydig细胞FasL表达及介导Jurkat细胞凋亡的影响。结果在睾丸局部感染时,VIP能调节Leydig细胞FasL表达格局并能调节Leydig细胞介导Jurkat细胞的凋亡率。结论VIP参与调节大鼠睾丸局部的免疫豁免。
Objective：To study the regulation of FasL expression in rat Leydig cells and of Jurkat cell apoptosis by Vasocation Intestinal peptide, nethods：UU-infected rats and their Leydig cells were treated with VIP. FasL expression in Leydig cells and the cell apoptosis were observed. Results：Under the UU-infected situation, FasL expressing pattern was mediated by the Leydig cells. Conclusion：VIP could regulate rat Leydig cell immune function and participate in the regulation of immune privilege of the testis.
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
2007年第4期291-295,共5页
Chinese Journal of Immunology
基金
上海市教委科研基金(04BB21)
上海市重点学科建设项目(T0206)资助
