摘要
瘙痒动物模型是研究瘙痒发生机制和开发止痒药物常用的动物模型,目前建立该模型的方法主要有直接使用特定种系动物法、炎症介质刺激法、化学物质刺激法和中枢吗啡注射法等。本文重点介绍上述方法在瘙痒机制或止痒药物研究中的应用,并简述现有对瘙痒模型的评价方法。
Itching models have been used in studying the mechanism of itch and antipruritics. To establish these models, methods of applying special germ lines of laboratory animals, stimulated with mediators of inflammation or chemical materials and injection of morphine in central were used. The application of these methods in investigations of itch or antipruritics and the evaluation of itching model have been introduced.
出处
《中国比较医学杂志》
CAS
2007年第3期182-186,共5页
Chinese Journal of Comparative Medicine
关键词
瘙痒
模型
动物
皮肤病
Itch
Models, animal
Dermatologic disease
