摘要
目的：研究ＴＮＦα在登革病毒发病中的作用，试图对登革病毒感染发病机理进行探讨。方法：以人脐静脉内皮细胞为靶细胞，研究肿瘤坏死因子（ＴＮＦα）对登革Ⅱ型病毒（Ｄ２Ｖ）增殖的影响；以及感染细胞产生ＴＮＦα能力的变化。结果：ＴＮＦα对人脐静脉内皮细胞中的Ｄ２Ｖ增殖有抑制作用；人脐静脉内皮细胞感染Ｄ２Ｖ后，感染细胞产生ＴＮＦα能力无明显改变。结论：ＴＮＦα在登革病毒感染发病中起重要作用。
Objective:To study the effect of TNF α in the pathogenesis of dengue fever.Methods:Using the endothelial cells(EC) from umbilical vein as the target cells,to study the effect of TNF α on multiplication of dengue Ⅱ virus(D 2V) and the ability of the infected EC to produce TNF α.Results:TNF α inhibited the multiplication of D 2V in EC,but the incease of the production of TNF α was not significant in EC infected with D 2V.Conclusions:TNF α play an important role in the pathogenesis of dengue fever.
出处
《蚌埠医学院学报》
CAS
1997年第2期71-73,共3页
Journal of Bengbu Medical College
