摘要
目的：探讨老年及老年前期抑郁障碍的心理和免疫功能改变。方法：对６３例年龄４５岁以上的抑郁病人以ＳＣＬ－９０、ＨＡＭＤ、ＨＡＭＡ、ＥＰＱ、ＬＥＳ等量表进行评定，三个月后随访评定，并进行单因素及多因素分析；对其中２９例病人取血进行淋巴细胞增殖试验及ＩＬ－２活性测定等，三个月后随访检测，并进行相关因素分析。结果：与１２名正常对照者比较，病人各量表总分、因子分及ＥＰＱ之神经质分显著增高，外周血淋巴细胞及ＩＬ－２活性显著降低。治疗三个月后，ＳＣＬ－９０、ＨＡＭＤ、ＨＡＭＡ总分及大部分因子分均下降，淋巴增殖显著增高，ＩＬ－２活性有所增高。结论：抑郁程度明显受人格、性别、婚姻状况及疾病类型等因素影响，抑郁程度越严重免疫功能受抑制越明显。
Objective:To examine clinical features, psychological profiles and changes in immunefunctions of senile and presenile depressive patients. Method: 63 patients aged 46 or above were administered a number of clinical and psychological scales including SCL-90, HAMD, HAMA, EPQ, and LES before and after a 3-month treatment period. Peripheral blood lymphocyte proliferation and IL-2 activity were monitored in 29 of the patients and 12 healthy controls. Result: Compared to healthy controls, the patients showed significantly elevated total scores and factor scores on all of the scales, as well as the N score in EPQ. On the other hand, lymphocyte proliferation and IL-2 activity were significantly lower in the patients as compared to controls. After treatment for 3 months, the total and factor scores of SCL-90, HAMD and HAMA decreased significantly, while levels of lymphocyte proliferation and IL-2 activity increased significantly.Conclusion: These results suggest that main factors influencing the degree of depression were personality, sex, marital status and classification of diseases. Immune functions were assessed to the severity of depression.
出处
《中国临床心理学杂志》
CSCD
1997年第2期83-86,82,共5页
Chinese Journal of Clinical Psychology
关键词
抑郁障碍
心理学
免疫功能
Senile, Presenile, Depressive disorder, Psychological profiles, Immune function
