摘要
对１３４例Ⅱ型糖尿病患者尿视黄醇结合蛋白、白蛋白、葡萄糖排泄及肌酐清除率（Ｃｃｒ）进行了检测，结果显示：①１３４例Ⅱ型糖尿病患者中，３９例（２９．１％）２４小时尿视黄醇结合蛋白（２４ｈｒＵＲＢＰ）排泄增加，其增高的发生率随尿白蛋白排泄增加而增加；正常、微量及大量白蛋白尿患者，其２４ｈｒＵＲＢＰ增高的发生率分别为１１．４％、４３．６％及７７．８％；②在微量及大量白蛋白尿患者中，２４ｈｒＵＲＢＰ增高者与２４ｈｒＵＲＢＰ正常者相比，Ｃｃｒ显著降低（Ｐ＜０．０５）。结果提示Ⅱ型糖尿病患者肾小管间质损害亦相当常见，并与肾功能减退有关。
The urinary retinol binding protein, albumin, glucose and creatinine clearance rate(Ccr) were determined in 134 patients with NIDDM. The results showed:① 39/134 patients had elevated 24hr urinary retinol binding protein excretion(24hrURBP). The prevalence of elevated 24hrURBP increased with increase of urinary albumin excretion, which was 11.4%,43.6% and 77.8% in patients with normo ,micro and macroalbuminuria respectively. ② Compared with the patients with normal 24hrURBP, Ccr in patients with elevated 24hrURBP was significantly reduced in patients who had micro and macroalbuminuria. Our results suggest that lesions of renal tubules and interstitium are also rather common and related with decrease of renal function in patients with NIDDM.
出处
《中国糖尿病杂志》
CAS
CSCD
1997年第2期93-95,共3页
Chinese Journal of Diabetes
关键词
糖尿病
视黄醇结合蛋白
检测
Retinol binding protein Renal tubular function
