摘要
目的：观察纳洛酮抢救地西泮急性中毒的疗效。方法：３３例地西泮急性中毒病人（男性４例，女性２９例；年龄２２±ｓ８ａ），在常规疗法基础上，静脉注射（静注）纳洛酮０．４～２．０ｍｇ，必要时２ｈ后重复静注；另有对照组４１例（男性５例，女性３６例；年龄２４±８ａ），仅用洗胃、输液等常规处理。结果：纳洛酮组在清醒时间、住院天数（Ｐ＜０．０１）和转归（Ｐ＜０．０５）等方面疗效优于对照组，纳洛酮组无明显不良反应。结论：纳洛酮抢救地西泮急性中毒病人疗效显著而又安全。
AIM: To observe the effects of naloxone in treating acute diazepam poisoning. METHODS: Thirty-three patients (M 4, F 29; age 22±s 8 a) with acute diazepam poisoning were treated with naloxone 0.4-2.0 mg, iv, in addition to conventional therapy(gastric lavage, infusion etc), and repeated iv after 2 h if necessary. Other 41 patients served as control (M 5, F 36; age 24± 8 a)were treated with the conventional therapy only. RESULTS: In comparison with the control, naloxone showed better effects in consciousness, time of hospitalization (P<0.01), and recoveries (P<0.05). Adverse reactions of naloxone were mild. CONCLUSION: The effects of naloxone in treating acute diazepam poisoning are notable and safe.
出处
《新药与临床》
CSCD
北大核心
1997年第1期29-30,共2页
关键词
纳洛酮
地西泮
中毒
naloxone
diazepam
poisoning
coma
