摘要
目的观察银杏达莫注射液对不稳定型心绞痛的治疗效果和对心肌QT离散度的影响及安全性。方法在常规治疗的基础上,治疗组加用银杏达莫注射液25 mL,稀释后静滴,qd;对照组加用葛根素注射液250 mL静滴,qd;疗程均为14 d。治疗期间密切观察患者心绞痛发作的次数、程度及药物的不良反应,视病情随时做心电图检查。治疗前后两组患者均做血、尿常规、肝肾功能、血脂、血液流变学及动态心电图检查。结果治疗组总有效率、对心肌QT离散度的改善与对照组比较有显著性差异,不良反应轻微。结论银杏达莫注射液治疗不稳定型心绞痛效果显著,能显著的改善心肌QT离散度,安全性好;还能显著的降低血脂和改善血液流变学。
OBJECTIVE To observe the curative effects of Ginkgo-Dipyridamolum on unstable angina pectoris and QT dispersion. METHODS 103 cases patients being hospitalized with unstable angina pectoris were randomly divided into Ginkgo-Dipyridamolum group （51 cases） and control group （52 cases）. Ginkgo-Dipyridamolum 25 ml was injected via intravenous every day in Ginkgo-Dipyridamolum group, and Puerarin injection 250 ml was injected via intravenous every day in control group being on routine treatment for 14 days. The changes of symptom; electrogram （ECG） and indexes of QT dispersion and lipidemid and hemorrheology in two groups were then observed. RESULTS The patient＇s symptom, electrogram （ECG） and indexes of QT dispersion in Ginkgo-Dipyridamolum group Were remarkably improved than those in control group. No changes in blood and urine routine examination as well as hepatic and nephtic function were found. CONCLUSION Ginkgo-Dipyridamolum has remarkable curative effect on unstable angina pectoris. It is safe and can remarkably improve the indexes of QT dispersion and lipidemid and hemorrheology.
出处
《中国现代应用药学》
CAS
CSCD
北大核心
2007年第3期179-182,共4页
Chinese Journal of Modern Applied Pharmacy
