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健择联合顺铂一线治疗晚期非小细胞肺癌40例临床观察 被引量:3

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摘要 目的:评价健择联合顺铂一线治疗晚期非小细胞肺癌(nonsmall-lung cancer,NSCLC)的近期疗效及毒副反应。方法:对40例经病理确诊、不能手术的NSCLC初治患者采用健择联合顺铂化疗,具体为第1、8天健择1250mg/m2,静滴30min;第1、2、3天顺铂25mg/m2,静滴,21天为1周期,至少完成2个周期后评价疗效,并观察不良反应。结果:总有效率(CR+PR)45.0%,中位疾病进展时间(MTTP)和中位生存期(MST)分别为7.1和10.8个月,主要的不良反应是骨髓抑制和恶心呕吐反应。结论:健择联合顺铂治疗晚期NSCLC疗效较好,毒性作用可以耐受,其剂量限制性毒性主要是骨髓抑制。
出处 《南京医科大学学报(自然科学版)》 CAS CSCD 北大核心 2007年第7期758-759,共2页 Journal of Nanjing Medical University(Natural Sciences)
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