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精卵细胞融合分子机制 被引量：2

Molecules Mechanism of Sperm-oocyte Fusion
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摘要 精卵融合是有性生殖中最为关键的事件之一,因此对该过程分子机制的理解具有十分重要意义。已经发现多种蛋白质涉及到这个重要的过程,主要包括卵子表面的CD9、GPI锚定蛋白和整合素等,精子表面的附睾蛋白DE、Izumo和ADAM家族成员等,它们通过特异性的识别和结合而辅助完成了精卵融合。这些进展对开发新的用于生殖调节或不育诊断和治疗技术、药物提供了保证。 Sperm-oocyte fusion is one of the most key events in sexual reproduction, so it has an important significance to understand its molecular mechanism. There are several molecules that involved in sperm-oocyte fusion, such as CD9, glycosylphosphatidylinositol-anchored proteins and integrins on oocytes, and epididymal pro- tein DE, Izumo and ADAMs on sperm. These molecules assist to complete sperm-egg fusion by special recognition and binding. These progress has vital application in developing new methods for both fertility regulation and diagnosis and treatment of human infertility.
作者 郭晓强 杨彩卿
机构地区 解放军白求恩军医学院生物化学教研室 保定师范专科学校定州分校
出处 《细胞生物学杂志》 CSCD 2007年第3期361-364,共4页 Chinese Journal of Cell Biology
关键词 精子 卵子 融合 sperm oocyte fusion
分类号 Q132.1 [生物学—普通生物学]
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参考文献39

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二级参考文献20

  • 1Tucker W.C.,Weber T.,Chapman E. R..Reconstitution of Ca^2+ -Regulated Membrane Fusion by Synaptotagmin and SNAREs.Science,2004.304(5669):435-438
  • 2Sudhof T.C.Synaptotagmins:Why So Many?J Biol Chem ,2002,277(10):7629-7632
  • 3Kreft M.,Kuster.V.,Grilc S.et al.Synaptotagmin I increases the probability of vesicle fusion at low [Ca^2+]in pituitary cells.Am J Physiol Cell Physiol,2003.284:C547-C554
  • 4Rickman C.,Davletov B..Mechanism of calcium-independent synaptotagmin binding to target SNAREs.J Biol Chem.2003.278(8):5501-5504
  • 5Earles C.A.,Bai J.,Wang P.et al.The tandem C2 domains of synaptotagmin contain redundant Ca^2+ binding sites that cooperate to engage t-SNAREs and trigger exocytosis.J Cell Biol.2001.154(6):1117-1124
  • 6Tucker W.C.,Edwardson J.M.,Bai J.et al.Identification of synaptotagmin effectors via acute inhibition of secretion from cracked PC12 cells.J Cell Biol,2003.162(2):199-209
  • 7Littleton J.T.,Bai J.,Vyas B.et al.synaptotagmin mutants reveal es sential functions for the C2B domain in Ca^2+ -triggered fusion and recyling of synaptic vesicles in vivo.J Neurasci,2001,21(5):1421-1433
  • 8Bai J.,Chapman E.R..The C2 domains of synaptotagmin—partners in exocytosis.Trends Biochem Sci,2004,29(3):143-151
  • 9Zhang X.,Kim-Miller M.J.,Fukuda M.et al.Ca^2+ -dependent synaptotagmin binding to SNAP-25 is essential for Ca^2+ -triggered exocytosis.Neuron,2002,34(4):599-611
  • 10Rickman C.,Archer D,A,, Meunier F,A. et al.Synaptotagmin interaction with the syntaxin/SNAP-25 dimer is mediated by an evolutionarily conserved motif and is sensitive to inositol hexakisphosphate.J Biol Chem,2004, 279(13):12574-12579.

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细胞生物学杂志
2007年 第3期

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