摘要
探讨多发性肌炎（ＰＭ）和皮肌炎（ＤＭ）骨骼肌组织损伤的免疫机制。方法采用免疫荧光一步法检测１８例ＰＭ／ＤＭ肌组织中免疫球蛋白ＩｇＧ、ＩｇＭ和补体Ｃ３的表达和分布。结果ＰＭ和ＤＭ肌组织中，ＩｇＧ、ＩｇＭ、Ｃ３的阳性表达率分别为６０％，３０％，２０％和７５％，３７．５％，５０％，其中ＩｇＧ的差别与对照组相比有统计学意义（Ｐ＜０．０５）；分布于小血管壁、肌膜和肌浆中的Ｉｇｓ／Ｃ３免疫复合物阳性率分别为３０％，５０％，３０％和８７．５％，５０％，３０％，其中ＤＭ肌组织中血管壁的分布与对照组相比有显著差异（Ｐ＜０．０５）。结论体液免疫在ＰＭ／ＤＭ发病机理中占重要位置，补体介导的血管损害参与皮肌炎病变的发展过程。
Objective\ To study the immunopathogenetic mechanisms of skeletal muscle injury in polymyositis(PM) and dermatomyositis(DM).\ Methods\ Expression and distribution of immunoglobulin IgG,IgM and complements C 3 were examined by direct immunofluence techniques in skeletal muscle of 18 cases PM and DM.\ Results\ The IgG,IgM and C 3 positive rates of PM and DM were 60%,30%,20% and 75%,37.5%,50% respectively,statistically significant more IgG was deposited in PM/DM compared with control(P<0.05).\ The immune complex positive rates of blood vessel wall,sarcolemma and sarcoplasma, were 30%,50%,30% in PM and 75%,50%,30% in DM respectively.\ There is statistically significant difference in the distribution of immune complex in blool vessel wall in skeletal muscle between DM and control groups(P<0.05).\ Conclusion\ Humoral immunity may play an important role in PM/DM pathogensis and the complement mediated vessel injury may take part in the development of DM.
出处
《福建医科大学学报》
1997年第2期158-160,共3页
Journal of Fujian Medical University
基金
福建省卫生厅青年基金
