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科学理解他汀类药物预防缺血性卒中/短暂性脑缺血发作的安全性 被引量：7

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摘要 随着流行病学和高质量临床研究的深入开展，神经科医生越来越关注他汀类药物在缺血性脑血管病防治中的重要作用。回顾我们在血脂领域的认识过程，经历了一个从模糊困惑到清晰明了的心路历程，现在以他汀类药物为代表的降脂治疗是防治心脑血管疾病的有效手段这一观点，已经得到普遍地认同。今天我们比以往任何时刻都更有理由、也更有条件科学地遵循血脂调控的指南，做出最佳的临床决策。
作者 王春雪 王拥军
机构地区 首都医科大学附属北京天坛医院神经内科
出处 《中华内科杂志》 CAS CSCD 北大核心 2007年第6期525-526,共2页 Chinese Journal of Internal Medicine
关键词 他汀类药物 短暂性脑缺血发作 缺血性卒中 药物预防 科学 安全性 缺血性脑血管病 心脑血管疾病
分类号 R743.3 [医药卫生—神经病学与精神病学]
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参考文献14

  • 1Amarenco P, Labreuche J, Lavallee P, et al. Statins in stroke prevention and carotid atheresclerosis: systematic review and up- to-date meta-analysis. Stroke, 2004,35:2902-2909.
  • 2Amarenco P, Bogousslavsky J, Callahan A 3rd, et al. High-dose atorvastatin after stroke or transient ischemic attack. N Engl J Med ,2006,355:549-559.
  • 3Guyton JR. Benefit versus risk in statin treatment. Am J Cardiol, 2006,97:95 C-97C.
  • 4Grotto AM Jr. Statins, cardiovascular disease, and drug safety. Am J Cardiol, 2006,97:3C-5C.
  • 5Thompson PD, Clarkson PM, Rosenson RS, et al. An assessment of statin safety by muscle experts. Am J Cardiol, 2006,97 : 69C- 76C.
  • 6Cohen DE, Anania FA, Chalasani N, et al. An assessment of statin safety by hepatologists. Am J Cardiol, 2006,97:77C-81C.
  • 7Jacobson TA. Statin safety: lessons from new drug applications for marketed statins. Am J Cardiol,2006, 97:44C-51C.
  • 8他汀类药物预防缺血性卒中/短暂性脑缺血发作的专家建议[J].中华内科杂志,2007,46(1):81-83. 被引量：124
  • 9Law M, Rudnicka AR. Statin safety: a systematic review. Am J Cardiol,2006,97 :52C-60C.
  • 10Schwartz GG, Olsson AG, Ezekowitz MD, et al. Effects of atorvastatin on early recurrent ischemic events in acute coronary syndromes: the MIRACL study: a randomized controlled trial. JAMA, 2001,285 : 1711-1718.

二级参考文献14

  • 1Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP)Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults ( Adult Treatment Panel Ⅲ). JAMA,2001,285 : 2486-2497.
  • 2Baigent C, Keech A, Keamey PM, et al. Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins. Lancet,2005,366 : 1267-1278.
  • 3Sacco RL, Adams R, Albers G,et al. Guidelines for prevention of stroke in patients with ischemic stroke or transiem ischemic attack: a statemem for healthcare professionals from the American Heart Association/American Stroke Association Council on Stroke: co-sponsored by the Council on Cardiovascular Radiology and Intervention: the American Academy of Neurology Affirms the value of this guideline. Circulation ,2006,113 : e409-e449.
  • 4Cannon CP,Steinberg BA, Murphy SA,et al. Meta-analysis of cardiovascular outcomes trials comparing intensive versus moderate statin therapy. J Am Coil Cardiol, 2006,48:438-445.
  • 5Amarenco P, Bogousslavsky J, Callahan A 3rd, et al. High-dose atorvastatin after stroke or transient ischemic attack. N Engl J Med, 2006,355:549-559.
  • 6Guyton JR. Benefit versus risk in statin treatment. Am J CardioI, 2006,97 (SA) :95C-97C.
  • 7Gotto AM Jr. Statins, cardiovascular disease, and drug safety. Am J Cardiol,2006,97(8A) :3C-5C.
  • 8Thompson PD, Clarkson PM, Rosenson RS, et al. An assessment of statin safety by muscle experts. Am J Cardiol,2006,97(8A) : 69C-76C.
  • 9Cohen DE, Anania FA, Chalasani N, et al. An assessment of statin safety by hepatologists. Am J Cardiol, 2006,97(8A) :T/C-81C.
  • 10LaRosa JC, Grundy SM, Waters DD, et al. Intensive lipid lowering with atorvastatin in patients with stable coronary disease. N Engl J Meal,2005,352:1425-1435.

共引文献123

同被引文献68

引证文献7

二级引证文献31

中华内科杂志
2007年 第6期

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