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89例肺癌脑转移病例放疗疗效分析 被引量:11

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摘要 目的评价全脑放疗+补充精确放疗与单纯全脑放疗对肺癌脑转移的疗效。方法将2003年1月-2004年12月在我院放疗科治疗的89例肺癌脑转移病人按治疗方法分为两组:即全脑放疗(WBRT)组41人,全脑放疗+补充精确放疗(WBRT+boost)组48人,其中采用三维适形补充放疗34例,等中心放疗14例。全脑放疗采用常规放疗技术,2 Gy/次,5次,周,DT:40 Gy。补充精确放疗采用三维适形或等中心技术,90%等剂量区,19 Gy/次,5次/周,DT:20.9 Gy。同时全组按照RPA分级标准Ⅰ、Ⅱ、Ⅲ级分为三组分别观察生存期其中Ⅰ级33人,Ⅱ级48人,Ⅲ级8人。结果WBRT+boost组有效率(CR+PR)91.67%(43/48)65.85%,其中CR 27例,明显高于WBRT组的65.85%(27/41),其中CR 14例(P<0.01)。WBRT+boost组与WBRT组中位生存期分别为13.6和9.9个月(P<0.05),一年生存率WBRT+boost组56.5%明显高于WBRT组的21.9%(P<0.01)。RPA分级标准Ⅰ、Ⅱ、Ⅲ级中位生存期分别为17.6个月、9.0个月、6.4个月(P<0.05)。其中无颅外转移的中位生存期15.4个月,有颅外转移的仅8.8个月(P<0.01)。两组急性放疗副反应无明显差别。结论全脑放疗+补充精确放疗可明显提高中位生存期和一年生存率,放射副反应未增加,是提高肺癌脑转移疗效的安全的治疗方法。
出处 《实用肿瘤学杂志》 CAS 2007年第3期238-243,共6页 Practical Oncology Journal
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参考文献12

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