摘要
目的:探讨cycin D1在鼻腔鼻窦肿瘤中的表达及其临床意义。方法:采用免疫组化SABC法检测20例鼻腔鼻窦恶性肿瘤和10例相应部位良性病变的石蜡标本中cycin D1的表达。结果:鼻腔鼻窦肿瘤中cycin D1表达均为阳性,良性病变中为阴性或弱阳性。鼻腔鼻窦恶性肿瘤中cycin D1积分与患者年龄、性别、病变部位及病理类型无关(P>0.05)。Cycin D1积分与TNM分期、病理分级相关(P<0.05),且积分随肿瘤临床分期、分级逐渐升高。初诊病例与复发病例之间cyclin D1积分差异有统计学意义(P<0.05)。结论:Cycin D1在鼻腔鼻窦肿瘤的发生、发展及复发转移等临床病理过程中起重要作用。
Objective： To investigate the expression of cyclin D1 in nasal sinus neoplasm and its clinical significance. Method： SABC immunohistochemical technique was used to determine the expression of cyclin D1 in 20 sampies of nasal sinus carcinoma and 10 samples of benign lesion. Results： Cyclin D1 was over-expressed in all nasal sinus carcinoma, whereas no or weak expression was determined in benign lesions. The cyclin D1 integral was not correlated with age, gender, site of tumor or pathologic type（P 〉 0.05） but correlated with the TNM stage and histological grade （P 〈 0.05）. Moreover, it gradually increased following the increase of stage and histological grade. There were significances between cyclin D1 integral of preliminary cases and recurrence cases （ P 〈 0.05）. Conclusion： Cyclin D1 may play an important role in tumor genesis.
出处
《山东大学耳鼻喉眼学报》
CAS
2007年第3期206-208,共3页
Journal of Otolaryngology and Ophthalmology of Shandong University
