摘要
目的:观察放疗与斯普林联合治疗局部晚期非小细胞肺癌的近期疗效及其对免疫功能的影响。方法:90例局部晚期非小细胞肺癌患者随机分为观察组(放疗+斯普林)、单放疗组。观察组放疗开始即行斯普林10mL/d(含25mg多肽)静脉点滴,连续应用4周,两组放疗方法、剂量相同。全部患者随访2年以上,随访率100%。结果:(1)观察组与单放疗组有效率分别为66.7%和33.3%(P<0.05)。1年生存率分别为71.1%和44.4%(P<0.05)。(2)观察组患者生活质量明显优干单放疗组(P<0.01)。(3)观察组治疗后和治疗前比较T细胞亚群,CD_3^+、CD_4^+、CD_4^+/CD_8^+比值升高,CD_8^+下降(P>0.05)。单放疗组治疗后与治疗前比较T细胞亚群,CD_3^+、CD_4^+、CD_4^+/CD_8^+比值下降,CD_8^+升高(P<0.05)。观察组与单放疗组治疗后比较T细胞亚群,CD_3^+、CD_4^+、CD_4^+/CD_8^+比值明显升高,CD_8^+明显下降(P<0.叭)。结论:放疗与斯普林联合治疗局部晚期非小细胞肺癌近期疗效优于单纯放疗,并能提高患者生活质量,改善患者自身细胞免疫功能。
Objective：To observed the short-term effects of Sipulin combined with radiotherapy on local advanced non small-cell lung cancer （NSCLC） and its influence on the immune function. Methods：Ninety patients with local advanced NSCLC were randomly divided into trial group （Sipulin plus radiotherapy） and the control group （only radiotherapy）. The patients in trial group were given Sipulin （ 10 mL/d, 25 mg peptide） by Bolus infusion combined with radiotherapy for 4 weeks. The patients in control group received only radiotherapy at the same dosage. All the patients were followed up for 2 years. The follow up ratio was 100%. Results： （ 1 ） The response ratio was 66.7% and 33.3% in trial group and control group, respectively （ P 〈 0.05 ）. The one-year survival rate was 71.1% and 44.4%, respectively （P 〈0.05）. （2） The life quality of the patients in trial group was much better than that in control group （P 〈0.05）. （3） The population of CD3^＋ cells, CD4 ^＋ cells and the ratio of CD4 ^＋/CD8 ^＋ were increased but the population of CD8 ^＋ cells were decreased after combined treatment. The population of CD3 ^＋ cells, CD4 ^＋ cells and the ratio of CD4 ^＋/CD8^＋ were decreased hut the population of CD8 ^＋ cells were increased after single radiotherapy （ P 〈 0.05 ）. Compared with control group, combined treatment induced a marked rise in the population of CD3^＋ cells and CD4^＋ cells and the ratio of CD4 ^＋/CD8 ^＋ and a fall in the population of CD8 ^＋ cells （P 〈0.01 ）. Conclusion： The short-term effect of Sipulin combined with radiotherapy on local advanced NSCLC is better than that of single radiotherapy. Combined therapy could improve the life quality and enhance the immune function of the NSCLC patients.
出处
《肿瘤》
CAS
CSCD
北大核心
2007年第6期493-495,共3页
Tumor
关键词
癌
非小细胞肺
放射疗法
免疫
斯普林
Carcinoma,non-small-cell lung
Radiotherapy
Immunity
Sipulin
