摘要
目的:研究缺氧诱导因子-1α(HIF-1α)、血管内皮生长因子(VEGF)在肾透明细胞癌(clear cell renal cell cancer.CC-RCC)和乳头状肾细胞癌(papillary renal cell cancer,PRCC)中的表达和相关性。方法:采用免疫组化法检测13例乳头状肾细胞癌、20例透明细胞癌及10例正常肾组织中HIF-1α,VEGF的表达,并比较它们之间的差异性及相关性。结果:HIF-1α在乳头状肾细胞癌、透明细胞癌及正常肾组织中阳性表达率分别为38,46%、85%、0,提示其表达在乳头状肾细胞癌组、透明细胞癌组与正常肾组织组之间差异有统计学意义(P<0.05)。VEGF在乳头状肾细胞癌、透明细胞癌及正常肾组织中阳性表达率分别为76.92%、90%、10%,乳头状肾细胞癌组与透明细胞癌组之间无显著性差异,但两组与正常肾组织组之间差异有统计学意义(P<0.05)。HIF-1α与VEGF的表达在乳头状肾细胞癌组中无相关性,在肾透明细胞癌组中呈正相关(r=0.79,P<0.001)。结论:在乳头状肾细胞癌组中HIF-1α低表达,VEGF高表达,但HIF-1α与VEGF的表达无相关性,提示乳头状肾细胞癌的肿瘤血管生成与透明细胞癌有所不同。
Objective：To study the expression of hypoxia inducible factor （HIF） -1 alpha and vascular endothelial growth factor （VEGF） in papillary renal cell cancer （PRCC） and clear cell renal cell cancer （CC-RCC） and the correlation between each other. Methods：The expressions of HIF-1 alpha and VEGF in PRCC （ n = 13 ）, CC-RCC tissues （ n = 20） and normal renal tissues （ n = 10） were detected by immunohistochemistry. The difference and correlation between each group were compared and analyzed. Results：The positive rates of HIF-1 alpha in PRCC, CC-RCC, and normal renal tissues were 38.46%, 85%, and 0% , respectively. There was significant difference between the three groups （P 〈0.05）. The positive rate of VEGF in PRCC, CC-RCC and normal renal tissues were 76.92%, 80%, and 10%, respectively. There was no significant difference between PRCC and CC-RCC. But the difference between renal cancer tissues and normal renal tissues was significant （ P 〈 0.05 ）. Expression of HIF-lalpha and VEGF had no correlation in PRCC tissues but had positive correlation in CC-RCC tissues. Conclusion：HIF-1 alpha is weakly expressed and VEGF is over-expressed in PRCC tissues. The expressions of HIF-lalpha and VEGF have no correlation. It suggests that the pattern of tumor angiogenesis in PRCC was different with CC-RCC.
出处
《肿瘤》
CAS
CSCD
北大核心
2007年第6期469-472,共4页
Tumor
关键词
肾肿瘤
缺氧诱导因子1
Α亚基
表皮生长因子
免疫组织化学
Kidney neoplasms
Hypoxia-inducible factor 1 ,alpha subunit
Epidermal growth factor
Immunohistochemistry
