摘要
目的:观察翻白草黄酮对糖尿病大鼠的抗氧化作用,并探究其作用机理。方法:翻白草经溶剂提取,聚酰胺柱分离提取得黄酮提取物;用四氧嘧啶腹腔注射造模,将造模成功的大鼠随机分成为高剂量(216mg·kg-1·d-1)、低剂量(108mg·kg-1·d-1)、模型组3组。连续给药14天后,观察翻白草黄酮对其胸腺指数、丙二醛(MDA)、超氧化物歧化酶(SOD)的影响。结果:给予翻白草黄酮后,胸腺指数上升、血清MDA含量下降、SOD含量增加与模型组比较有显著性差异。结论:翻白草黄酮对糖尿病大鼠的治疗作用,可能是通过提高抗氧化能力和增强免疫力来实现。
Objective： To study the effects of flavonoids from Potentilla Discolor Bunge（FPB） on the Antioxidation level in diabetes rat and try to find its mechamisrus . Methods： FPB were obtained from Potentilla Discolor Bunge through solvent extraction and polyamide columnar Chromatography , Using the rat model of alloxan-diabetes were randomly divided into three groups： high dose group（216mg·kg^-1·d^-1） ,low dose group（ 108 mg·kg^-1·d^-1 ） and model group, thymus index was concluded, ,SOD activity and MDA contend of serum were measured after 14 days, Results： FPB enhanced the thymus index and SOD activity values and decreased MDA contend Conclusion： FPB increase the antioxidation and the cell immunefunction to protect the diabetes rat.
出处
《江西中医学院学报》
2007年第3期64-65,共2页
Journal of Jiangxi College of Traditional Chinese Medicine
基金
江西省卫生厅资助项目(No.2006A05)
