摘要
用免疫组化方法检测正常肝和肝癌组织中的P53蛋白表达，结果：肝癌的P53蛋白阳性率达63．6％，正常肝组织为0；并发现P53蛋白的表达强度与肝癌的转移、病理分级、预后呈正相关。说明P53蛋白检测对判断肿瘤的恶性度和预后有重要意义。
In order to study the relationship between P53 gene mutation and the occurrence and prognosis of Hepatocellular cancer. Expression of P53 protein was examined by means of immunohistochemical method 1. The results showed that P53 protein expression was high in 63. 6% of Hepetocellular carcinoma and in normal liver tissue that was negative. Meanwhile,the study also found that the degree of P53 protein expression was significantly corrlated with the degree of tumor cell differentiation、invation、 metastasis and prognosis. Examination of P53 expression is of valuable in understanding. The degree of malignancy and evaluating prognosis of thedisease.
出处
《苏州医学院学报》
1997年第1期21-22,198,共2页
Acta Academiae Medicinae Suzhou
关键词
P53
预后
肝肿瘤
Hepatocellular carcinoma
protein P_(53)
prognosis
