摘要
目的：总结我中心4年40例亲属活体肾移植的经验.方法：40例患者中3例为夫妻间供肾,其余为血缘亲属供肾.术前均行HLA配型、PRA及淋巴毒试验检查.手术全为开放手术取肾,取左肾32例,右肾8例;受者均为第一次接受肾移植手术.术后以环孢素A（或他克莫司）、霉酚酸酯及泼尼松三联抗排斥反应治疗.结果：供者术后1周内出院,随访至今,肾功能均正常.受者术后36 d内出院,出院时肾功能正常,随访2～48月,未见肾功能异常病例. 结论：术前对供、受者的正确评价及成熟的手术技术是手术成功的保证,术后坚持随访和合理应用免疫抑制剂是受者长期存活的关键.亲属活体肾移植组织配型好,术前可充分准备,术后用药量少,手术成功率和长期存活率高,是一种安全可靠经济的治疗手段.
Objective： To introduce one-center experience on forty cases living-related donor kidney transplantation （LDKT） in the past four years. Methods：Forty patients underwent LDKT. Potential living donors （15 males and 25 females） underwent fully medical evaluation before operation. Except 3 cases being donated by spouse, the others were donated by blood relationship donors. HLA matching, PRA and CDC were done pre-operations. All the donors underwent open nephrectomy , in which 8 cases donated right kidneys and 32 cases donated left kidneys. All the recipients underwent the first renal transplantation. Triple-combined immunosuppressive protocols consisted of calcineurin inhibitors （CNI） , MMF/ Aza and steroid. Results：All donors were discharged in ten days postoperation. After followed-up for 2 months to 48 months, all the donors kept normal kidney function without impairment of life quality. All the recipients were discharged in thirty-six days with normal kidney function, and grafts keeps good function up to now. Conclusion：Both accurate pre--operation assessment of the donor and recipient and good surgical technique are critical for the success. Optimal HLA matches and reasonable using of immunosuppressants can make the grafts survived long-term. Living-related donor kidney transplantation has optimal HLA matches, better preparation preoperation and low-dose immunosup- pressants, so the operation achievement ratio and long--term surviving ratio are higher than cadaver renal transplantation. It is a safe and economic treatment.
出处
《实用临床医学（江西）》
CAS
2007年第5期5-8,共4页
Practical Clinical Medicine
关键词
肾移植
活体供者
亲属
kidney transplantation
living donors
related
