摘要
目的探讨冠心病患者血清白细胞介素-18（IL-18）水平与冠状动脉内斑块性质的相关性。方法对22例稳定型心绞痛（SA）、34例不稳定型心绞痛（UA）和28例急性心肌梗死（AMI）患者行冠状动脉造影,其中SA21例,UA22例,AMI25例,共162支冠状动脉行血管内超声（IVUS）检查;随机抽取冠状动脉造影（CAG）阴性者20例为对照组（NS）;根据IVUS结果和脂质斑块的含量,分为4组：A组含脂质斑块0-25%,B组26%-50%,C组51%-75%,D组76%-100%;检测所有患者的IL-18血清水平。结果随着冠心病危险分层的升高,血清IL-18也升高：对照组（25.5±11.5）pg/mL,SA组（50.6±13.5）pg/mL,UA组（76.2±10.6）pg/mL,AMI组（108.4±11.2）pg/mL,差别具有统计学意义（P〈0.05）。随着脂质斑块含量的增多,血清IL-18逐渐升高：A组（34.5±11.5）pg/mL,B组（51.6±12.6）pg/mL,C组（176.4±10.2）pg/mL,D组（205.4±13.2）pg/mL,差别具有统计学意义（P〈0.05）。结论IL-18可能可以作为冠心病危险性的预测因子,血清IL-18水平有可能成为早期辨别斑块不稳定性的指标。
Objective To investigate the relationship between the serum level of interleukin-18 and the characterization of coronary artery plaques in different subtype of coronary artery disease. Methods Angiography was performed on 21 patients with stable angina（SA）, 33 patients with unstable angina（UA）and 28 patients with acute myocardial infarction（AMI）. Intravascular ultrasound（IVUS） was performed in 21 SA, 25 UA and 22 AMI, including 162 coronary arteries. 20 cases with negative result in coronary angiography were selected as the control group（NS）. With IVUS-VH, the patients were divided into four groups（A,B,C and D） according to the lipid plaques ratio. The lipid plaques ratio of group A was 0-25%, B was 26%-50% ,C was 51%-75%, D was 76%-100%. Serum of IL-18 were measured with enzyme-linked-immonosorbent assay（ELISA） in all patients. Results The levels of IL-18 in each group were, NS（25.5 ± 11.5） pg/mL, SA（ 50.6 ± 13. 5） pg/mL, UA（76.2 ± 10.6） pg/mL, AMI （108. 4±11. 2）pg/mL respectively. The IL-18 levels of group A were （34. 5±11. 5）pg/mL, B were （51.6±12.6）pg/mL,C were （176.4±10.2）pg/mL and D were （205.4±13.2）pg/mL. With the increasing of the lipid plaques ratio, the serum levels of IL-18 were increased （P〈0.05）. Conclusion The serum levels of IL-18 may reflect the risk of coronary artery disease and may be as the predictable index of the coronary plaques.
出处
《福建医科大学学报》
2007年第3期242-244,共3页
Journal of Fujian Medical University
