摘要
目的 观察抗感染活性骨（anti—infective reconstituted bone xenograft，ARSX）Ⅰ期植骨治疗开放性骨损伤的疗效。方法（1）实验研究：将ARBXI期植入细菌污染的兔胫骨骨缺损中，通过影像学、组织学、细菌学检测手段，评价其修复骨损伤和预防感染的效果。（2）临床研究：治疗开放性骨损伤患者33例，对其中18例获得6个月以上系统随访的患者进行疗效分析。结果（1）实验研究：ARBX可Ⅰ期植骨，有效修复细菌污染的兔胫骨骨缺损。（2）临床研究：18例患者除2例发生延迟连接外，均获得满意骨愈合；无一例出现骨感染。结论 ARBX具有高效成骨活性和强力抗感染能力，能Ⅰ期植骨促进开放性骨损伤有效修复，并能显著降低继发感染的发生率。
Objective To study the effect of anti-infective reconstituted bone xenograft （ARBX） on treating open fractures as primary grafting. Methods 1. Experimental study： ARBX was implanted as primary bone graft into contaminated bone defects in the tibia of rabbits to radiographically, histologically and bacteriaologically evaluate its effectiveness in both preventing bone infection and repairing contaminated bone defects. 2. Clinical study： Finally, ARBX was used to treat 18 cases with open fractures. Results 1. Experimental study： ARBX could be used as primary bone graft to repair a contaminated bone defect in the tibia of rabbits, which would effectively prevent osteomyelitis from occurrence. 2. Clinical study： All 18 cases with open fractures undergone the treatment with ARBX were followed up for 6-63 months, which showed satisfactory results. Conclusions ARBX has high osteoinductive activity and an enhanced anti-infective capability, which enables it to be used as primary grafting to treat open fractures.
出处
《中华创伤杂志》
CAS
CSCD
北大核心
2007年第6期417-420,共4页
Chinese Journal of Trauma
基金
全军“十五”重点课题基金资助项目（01Z079）
关键词
骨折
开放性
感染
骨
骨移植
庆大霉素
Fractures, open
Infection, bones
Bone transplantation
Gentamicin
