摘要
目的:总结Neuritin基因表达调控、分子特征及在神经再生领域的研究。资料来源:应用计算机检索Pubmed和Springlink数据库2005-01/2006-10相关神经营养因子Neuritin、神经再生方面的文献,检索词“Neuritin、nerve regeneration”,限定文献语言种类为English。资料选择:对资料进行初审,选取包括Neuritin的全部文献和神经再生相关的文献,开始查找全文。纳入标准:与神经再生有关的神经营养因子的机制研究。排除标准:神经再生相关的药物及功能研究。资料提炼:在Pubmed共检索到与Neuritin相关的文章17篇,在Springlink检索到49篇与神经再生相关的生物医学和生命科学的文献,最终纳入39篇符合标准的文献。资料综合:Neuritin是一种新近发现的与神经可塑性相关的神经营养因子,能促进树突和轴突的生长和突触成熟,调节突触回路的形成。它是一条编码糖基磷脂酰肌醇锚定的糖蛋白基因,在神经组织中表达最多,其中以齿状回最高,其次为海马,大脑皮层和小脑。Neuritin作为神经活动和神经营养素发挥作用的共同下游因子,在促进突触成熟、防止神经细胞凋亡、保护运动神经元和促进血管生成等方面具有重要作用。本文就Neuritin的生物学特性及在神经再生领域的研究做一综述。结论:Neuritin作为一种新的、与神经可塑性相关的营养因子,在神经再生领域中具有潜在的、良好的应用前景。
OBJECTIVE： To review Neuritin genetic expression, regulation, molecule character and the research in the field of nerve regeneration.
DATA SOURCES： Applying computer to search Pubmed and Springlink databases to identify relevant literatures of Neuritin and nerve regeneration published between January 2005 and October 2006, with the key word of Neuritin and nerve regeneration, language was limited to English.
STUDY SELECTION： All literatures of Neuritin and relevant literatures to nerve regeneration were selected after preliminary inspection to data, then the full-texts were looked up. Inclusive standard： the articles of mechanism research for nerve regeneration relevant neurotrophic factors. Exclusive standard： research for nerve regeneration relevant medicines and function.
DATA EXTRACTION： Totally 17 research literatures about Neuritin were screened in Pubmed, while 49 literatures were researched in Springlink related to nerve regeneration in the field of biomedicine and life science, finally 39 articles were brought into standard literatures.
DATA SYNTHESIS： Neuritin is a newly discoverable neurotrophic factor related to neural plasticity, and can improve the growth of dendrite and axon, together with the synapsis mature, regulate the formation of synapse circuit. It is a glycoprotein gene encoded glycosylphosphatidylinositol anchoring, and is expressed maximum in nervous tissue, among the total, the highest is gyrus dentatus, next is hippocampus, cerebral cortex and cerebellum. Neuritin is the common downstream factor for nervous activity and neurenergen to have important effects in promoting synapsis mature, preventing nerve cell apoptosis, protecting motoneuron and promoting angiogenesis. This paper is aimed to review the biological character and the research in the field of nerve regeneration.
CONCLUSION： Neuritin as a new nutrition factor related to neural plasticity has potential and favorable application prospect in the field of nerve regeneration.
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2007年第19期3813-3816,共4页
Journal of Clinical Rehabilitative Tissue Engineering Research
基金
国家自然科学基金(30260029)~~
