摘要
目的探讨苯巴比妥(pentobarbital,PB)对豚鼠下丘(inferior colliculus,IC)和听皮层(auditory cortex,AC)间隔响应阈值、幅值及潜伏期的影响。方法在豚鼠IC和AC分别埋植慢性电极,比较清醒和两种剂量(20mg/kg和40mg/kg)PB麻醉状态下的间隔响应阈值、幅值和潜伏期。结果PB使间隔响应阈值升高,其中对AC的影响大于IC。在IC,只有大剂量PB使间隔响应阈值升高;而在AC,两种剂量PB均使间隔响应阈值升高。PB还对豚鼠IC和AC阈上间隔响应的潜伏期和幅值产生不同的影响。结论PB可降低豚鼠以间隔响应阈值为代表的时间分辨率。
OBJECTIVE To explore the effect of pentobarbital （PB） on gap responses recorded from inferior colliculus （IC） and auditory cortex （AC） of guinea pigs. METHODS Chronic electrodes were implanted in IC and AC of guinea pigs. The response to gaps embedded in noise was recorded in awake, and when animals were anesthetized with PB at two doses： 20mg/kg and 40mg/kg. The threshold, amplitude and latency of the gap responses form IC and AC were compared across the three conditions. RESULTS PB increased the threshold of gap responses in both IC and AC, with larger impact on AC. PB effect on IC responses was only significant at the higher dose, while this significance was seen at both doses in AC responses. PB also produced different effects on supra-threshold response latency and amplitude of in AC and IC. CONCLUSION Indicated by the increasing gap response threshold, PB decreases the temporal resolution of IC and AC in guinea pigs.
出处
《中国耳鼻咽喉头颈外科》
北大核心
2007年第1期51-55,共5页
Chinese Archives of Otolaryngology-Head and Neck Surgery
基金
国家自然科学基金资助项目(30672294)
关键词
苯巴比妥
豚鼠
听觉
下丘
听觉皮层
Penobarbital
Guinea Pigs
Auditory Perception
Inferior Colliculus
Auditory Cortex
