摘要
喜树碱是一种重要的抗癌药物,它通过选择性作用拓扑异构酶I(Top I)而发挥抗癌作用。由于喜树碱存在毒性大、溶解性能差以及体内稳定性差等不足,限制了它的临床应用。文章主要综述喜树碱7,9,10,20-位衍生物的研究进展,目标在于降低它的毒性,提高体内环境下的稳定性和溶解性,使其应用更广泛。
Camptothecins are an important antitumor drug which can selectively interfere with the breakage-reunion reaction of the topoisomerase Ⅰ （Top Ⅰ ）. The recent developments of the 7,9,10,20 derivatives of camptothecins are reviewed. The aim of the study is to reduce the toxicity of camptothecins and improve their stability and solubility so as to use them more widely.
出处
《合肥工业大学学报（自然科学版）》
CAS
CSCD
北大核心
2007年第5期579-582,共4页
Journal of Hefei University of Technology：Natural Science
基金
合肥工业大学制药工程创新人才培养基地项目(033034)
关键词
喜树碱
衍生物
水溶性
稳定性
camptothecin
derivative
solubility
stability
