摘要
骨髓间充质干细胞是一种多潜能干细胞。在体外培养时,多种诱导因素可使其分化为心肌细胞等。目前进行的动物实验和临床研究表明骨髓间充质干细胞具有促进血管增生以及改善心肌梗死后心脏功能的作用,为受损心肌的治疗提供了广阔前景。但是其修复受损心肌的机制仍具有很大争议。就以上内容进行综述。
Bone marrow mesenchymal stem cells （MSCs）, multipotent stem cells, can replicate as undifferentiated cells and have the potential to differentiate into different lineages of mesenchymal tissues, including bone, cartilage, endothelial, neural, smooth muscle, skeletal myoblasts, and cardiac myocyte cells. The ischemia-induced death of cardiomyocytes results in scar formation and reduced contractility of the ventricle. Several preclinical and clinical studies have supported the notion that MSCs therapy may be used for cardiac regeneration. When transplanted into the infracted heart, MSCs prevent deleterious remodeling and improve recovery, but the mechanism is not clear. In this work, we review evidence and new prospects that support the use of MSCs in cardiomyoplasty.
出处
《中国生物工程杂志》
CAS
CSCD
北大核心
2007年第6期107-110,共4页
China Biotechnology
基金
国家自然科学基金资助项目(30370365)
"973"资助项目(2006CB705704)
关键词
骨髓间质干细胞
细胞移植
细胞融合
旁分泌作用
Mesenchymal stem cells Cell transplant Cellular fusion Paracrine effects
