摘要
目的观察咪达普利对老年高血压病降压治疗的有效性及安全性。方法选择符合条件的原发性高血压124例,随机分为两组,卡托普利组(n=58)口服卡托普利片25 mg,3次/d;咪达普利组(n=66)每日晨起口服咪达普利片10 mg,共4周。分别记录用药前和用药后1、2、3、4周的血压和心率,并比较用药前后的血、尿常规及生化指标,检查眼底、心电图、胸透以了解靶器官的受累情况。结果A、B两组患者中,显效、有效及总有效率分别为63.79%、13.79%、77.58%、65.15%、13.64%、78.79%。卡托普利组治疗2周后与咪达普利组治疗1周后各时点血压值较治疗前均有显著下降(P<0.05);服药4周后,组间比较差异无统计学意义(P>0.05),两组治疗前后心率无明显变化(P>0.05)。不良反应发生率咪达普利组(7例,占10.6%)少于卡托普利组(15例,占25.86%)(P<0.05)。结论咪达普利治疗老年高血压与卡托普利降压效果相近,且患者依从性好,副作用少。
Objective To evaluate the efficacy and safety of imidapril in old Patients with hypertension, comparing with captopril. Methods 124 cases of primary hypertension were divided into two groups. Group A was administrated with oral captopril at the dosage of 25mg tid, and group B imidapril, 10mg in the morning. The medication lasted for 4 weeks. In order to investigate conditions of the target organs, some signs of the patient before and after medical treatment were studied, such as Blood Pressure, Heart Rate, blood routine indicators, urine routine indicators, biochemical markers, eye ground, electrocardiogram and chest X - ray. Results The rate of excellence, utility, and total effectiveness were 63.79%、13.79% ,77.58% and 65.15% ,13.64% ,78.79%, respectively between group A and group B. Blood pressure decreased significantly after two week treatment in group A and one week in group B. Heart rate did not differ in two groups. Adverse effect rate was 25.86% in group A and 10.6% in group B. Conclusion Imidapril has the same efficacy as captopril and better compliance and safety.
出处
《中国临床保健杂志》
CAS
2007年第3期261-262,共2页
Chinese Journal of Clinical Healthcare
