摘要
基质金属蛋白酶通过参与细胞表面和细胞外基质蛋白的降解或激活过程来调控细胞与细胞之间、细胞与细胞外基质之间的相互作用,是正常细胞与肿瘤细胞微环境的重要调节者。有关基质金属蛋白酶家族在肿瘤学中作用的研究发展迅速,部分研究结果已应用于临床,基质金属蛋白酶抑制剂可能会成为今后治疗肿瘤的有效方法。现就基质金属蛋白酶在妇科肿瘤如卵巢癌、子宫内膜癌和宫颈癌中的作用进行综述。
By participating degeneration or activation of matrix proteins on the cell surface and in intercellular space, matrix metalloproteinases regulate interactions of cellular-cellular and intra-extra cellular matrix. They are important modulators of microen-vironment of normal and tumor cells. The research on roles of the matrix metalloproteinase family in oncology has achieved great progress. Some research results have been used in clinic. Matrix metalloproteinase inhibitors may become an effective drug to treat tumor in future. The article reviewed the roles of matrix metalloproteinases in treatment of three major malignant gynecological tumors--ovarian carcinoma, endometrial carcinoma and cervical carcinoma.
出处
《中国妇幼健康研究》
2007年第3期243-245,共3页
Chinese Journal of Woman and Child Health Research
关键词
基质金属蛋白酶
卵巢癌
子宫内膜癌
宫颈癌
恶性
matrix metalloproteinase
ovarian carcinoma
endometrial carcinoma
cervical carcinoma
malignant
