摘要
目的观察新生儿缺氧缺血性脑病(HIE)时脐血肌酸激酶脑型同工酶(CK-BB)及神经元特异性烯醇化酶(NSE)水平变化,早期诊断新生儿缺氧缺血性脑损伤,为临床早期诊断新生儿缺氧缺血性脑损伤及协助HIE分度,估计预后提供一定的依据。方法20例足月儿,出生后1分钟Apgar>9分的新生儿为对照组,32例诊断为新生儿缺氧缺血性脑病的新生儿为病例组,生后立即收集脐血,检测CK-BB及NSE值。结果新生儿HIE组脐血CK-BB及NSE水平明显高于对照组,差异显著(P<0.01),且和HIE程度呈正相关。结论新生儿缺氧缺血性脑病(HIE)组脐血CK-BB及NSE水平高于对照组,差异显著。CK-BB,NSE水平变化可作为反映早期脑损伤的生化指标。协助HIE分度,估计预后,进行早期干预,具有一定的临床价值。
Objective： The research was aimed to study the change of NSE, CK-BB in serum of newborns with hypaxic -isch-emicencephalopathy and make out the relationship between the HIE patients and the function of throid. Methods ： There were 20 neonates without the symptoms of fetal distress and Apgar score ≥9 in the control group. There were 32 neonates with HIE in the study group. All neonates were measured for umbilical artery CK - BB and NSE levels at delivery. Reasults ： The results showed that the NSE, CK - BB in serum With HIE was significantly higher than normal control （ P 〈 0. 01 ）. Conclusion ： The levels of Cord blood and NSE and CK - BB is the symbol reflecting the early damages of brain. Our findings suggest that NSE and CK - BB in serum are reliable biochemical markers for early estimates of hypoxic - ischemic brain damage and have great value to judging the stage of HIE cor- rectly.
出处
《中国优生与遗传杂志》
2007年第6期37-38,共2页
Chinese Journal of Birth Health & Heredity
