摘要
目的探讨冠心病(CHD)患者血清超敏C反应蛋白(hs-CRP)水平与冠状动脉狭窄程度的相关性。方法采用胶乳增强免疫透射比浊法检测经冠状动脉造影(CAG)确诊的CHD患者100例和CAG结果正常者40例的血清hs-CRP浓度,同时采用Gensini评分系统对CHD患者冠状动脉血管病变程度进行定量评分,并分析hs-CRP与Gensini评分间的关系。结果血清hs-CRP浓度在单支冠状动脉病变组、双支冠状动脉病变组及三支冠状动脉病变组依次增高,均显著高于对照组,差异有统计学意义;且CHD患者血清hs-CRP水平与Gensini积分呈显著正相关(r=0.316,P<0.01)。结论血清hs-CRP水平与冠状动脉病变的程度有相关性,可作为临床评价冠状动脉狭窄程度的指标之一。
Objective To investigate the correlation of serum high-sensitivity C-reactive protein （hs-CRP） with coronary stenosis degree in patients with coronary heart disease （CHD）. Methods Latex-enhanced immunity transmission turbidity method was applied to measuring the serum hs-CRP concentrations in both 100 CHD patients confirmed by coronary angiography （CAG） and 40 controls with normal CAG findings, and Gensini score system was utilized to quantitatively assess the coronary lesion extent in CHD patients. Finally, the correlation of hs-CRP levels and Gensini scores was analyzed. Results Serum hs-CRP concentration gradually increased in single-vessel, doublevessel to multi-vessel lesion groups, with significantly higher elevations as compared with that of the control group, showing statistical differences between them. And serum hs-CRP level in CHD patients was positively relative to Gensini score （r=0. 316 ,P〈0.01）. Conclusion Serum hs-CRP level may be positively associated with coronary lesion degree, serving as one of the indicators for assessing coronary stenosis degree.
出处
《检验医学与临床》
CAS
2007年第6期468-469,共2页
Laboratory Medicine and Clinic
