摘要
选择腹部手术病人130例(ASAI～Ⅱ),随机分成7组.应用吗啡、氯胺酮、布吡卡因等硬膜外术后止痛,并与生理盐水对照双盲法观察研究。结果显示:起效时间以布吡卡因类药物最快,吗啡次之,氯胺酮较慢(P>0.05)。镇痛效果以布吡卡因类及吗啡更为确切,氯胺酮较差,生理盐水亦有少数出现镇痛。镇痛持续时间:吗啡组>布吡卡因组>氯胺酮组>对照组, 在布吡卡因各组中,0.25%布吡卡因+维生素B_(12)>0.25%布吡卡因≈0.375%布吡卡因≈0.25%布吡卡因+肾上腺素。作者对不同药液硬膜外术后镇痛的并发症及药物选择进行了讨论。
130 abdominal surgical patients ( ASA I-II ) were randomly divided into seven groups and epidural 0.9% normal saline and a doubleblindstudy were taken as control.The results of observation showed that the effective time of epidural bupivacine was shortest, that of epidural morphine was shorter and epidural ketamine was short, without marked different ( P>0.05 ) .The analgesic effect of epidural bupivacine and morphine was better than that of epidural ketamine. Few patients after epidural injections with physiological saline had analgesia. The continuous time of easing pain in all these groups was showed as follows: epidural group>bupivacine gourp>ketamine group>controlgroup, and in
each of bupivacine greups, epidural 0.25% bupivacine+ vitamine B12>epidural 0.25% bupivacine = epidural 0.375% bupivacine = epidural 0.25% bupivacine+epinephrine. We discused the complications due to different drugs for postoperative relief after epidurai injections and the clioise of different drugs for postoperative analgesia.
出处
《赣南医学院学报》
1990年第1期22-24,68-69,共3页
JOURNAL OF GANNAN MEDICAL UNIVERSITY
关键词
镇痛药物
硬膜外注射
药效学
止痛
Analgesia/drug effects
Morphine/phaymacodymamics
Ketamine/pharmacodymamics
Bupivacine/pharmacodymamics
Controlled clinical trials
