摘要
目的探讨嗜酸粒细胞性支气管炎(eosinophilic bronchitis,EB)和哮喘患者的咳嗽敏感性与其咳嗽发病机制的关系。方法采用辣椒素咳嗽激发试验,测定EB、咳嗽变异型哮喘(cough variant cough,CVA)及典型哮喘(Asthma)患者的咳嗽敏感性,并以正常人作为对照。结果正常对照、EB,CVA和Asthma各组的LogC2分别为1.92±0.35,1.01±0.43,1.07±0.64,2.05±0.59,EB组显著低于正常对照组、CVA及Asthma组(均P<0.01)。对照、EB、CVA和Asthma各组的LogC5分别为2.61±0.40,1.55±0.72,2.34±0.60,2.25±0.48,EB组显著低于对照、CVA及Asthma组(均P<0.01)。结论EB患者的辣椒素咳嗽敏感性显著升高,提示C纤维末梢敏感性增高是EB咳嗽的发病机制之一。
Objective To investigate the pathology of cough in eosinophilic bronchitis （EB） and asthma by observing the cough reflex sensitivity in EB ,cough variant asthma （CVA） and classic asthma patients. Methods Capsaicin challenge tests for measuring cough reflex sensitivity were performed in patients with EB ,CVA and classic asthma,as well as in healthy volunteers. Results The mean value of LogC2 in subjects with EB 1.01 20. 43 was significantly lower than normal subjects 1.92 ± 0. 35, CVA 1.70 ± 0. 64 and classic asthma 2.05 ± 0. 59, （ P 〈 0. 01 ）. The mean value of LogC5 in subjects with EB 1.55 20. 72 was significantly lower than that of normal subjects 2. 61 ±0.40,CVA 2. 34 20. 60, and classic asthma 2.25 ±0.48, （P 〈0. 01 ）. Conclusion The increased cough reflex sensitivity to capsaicin is a physiologlcal characteristic of EB patiens, which may be one of the mechanisms of cough in EB.
出处
《广东医学》
CAS
CSCD
北大核心
2007年第6期897-899,共3页
Guangdong Medical Journal
基金
广州市医药卫生科技项目(编号:2006-YB-239)
广州市科技攻关项目(编号:2004Z3-E0541)
