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白血病干细胞的靶向治疗 被引量：1

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摘要 现今，白血病的治疗已经由单纯的传统细胞毒药物发展到干细胞移植、靶点药物的应用等多种方式和手段的综合治疗，使白血病缓解率大大提高。尽管如此，难治、残留、复发仍然是白血病治疗的巨大障碍和亟待解决的难题。
作者 杨纯正
机构地区 中国医学科学院血液学研究所 实验血液学国家重点实验室
出处 《中华医学杂志》 CAS CSCD 北大核心 2007年第20期1372-1374,共3页 National Medical Journal of China
关键词 白血病干细胞 靶向治疗 细胞毒药物 干细胞移植 综合治疗 缓解率 靶点 难治
分类号 R733.7 [医药卫生—肿瘤]
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参考文献20

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同被引文献9

  • 1Ravandi V,Estrov Z.Eradication of leukemia stem cells as a new goal of therapy in leukemia.Clin Cancer Res,2006,12:340-344.
  • 2de Figueiredo-Pontes LL,Pintao MC,Oliveira LC,et al.Determination of P-glycoprotein,MDR-related protein 1,breast cancer resistance protein,and lung-resistance protein expression in leukemic stem cells of acute myeloid leukemia.Cytometry B Clin Cytom,2008,74:163-168.
  • 3Dean M,Fojo T,Bates S.Tumour stem cells and drag resistance.Nat Rev Cancer,2005,5:275-284.
  • 4Eyler CE,Rich JN.Survival of the fittest:cancer stem cells in therapeutic resistance and angiogenesis.J Clin Oncol,2008,26:2839-2845.
  • 5Puissant A,Grosso S,Jacquel A,et al.Imatinib mesylateresistant human chronic myelogenous leukemia cell lines exhibit high sensitivity to the phytoalexin resveratrol.FASEB J,2008,22:1894-1904.
  • 6de Jonge-Peeters SD,Kuipers F,de Vries EG,et al.ABC transporter expression in hematopoietie stem cells and the role in AML drug resistance.Crit Rev Oncol Hernatol,2007,62:214-226.
  • 7Raaijmakers MH.ATP-binding-cassette transporters in hematopoietic stem cells and their utility as therapeutical targets in acute and chronic myeloid leukemia.Leukemia,2007,21:2094-2102.
  • 8Ho MM,D Hngge E,Ling V.MDR1 and BCRP1 expression in leukemic progenitors correlates with chemotherapy response in acute myeloid leukemia.Exp Hematol,2008,36:433-442.
  • 9魏虎来,姚小健,李宇宁,王蓓,赵怀顺,白德成,彭晓,马兰芳.三氧化二砷抑制K562/ADM细胞P-糖蛋白表达并提高化疗药物的敏感性[J].中华血液学杂志,2003,24(1):28-31. 被引量：21

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中华医学杂志
2007年 第20期

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