摘要
为阐明常年性变应性鼻炎患者在ＨＬＡ单倍型方面有无特征表现及其遗传背景的实质，我们用血清学方法对３１例中国南方汉族患者进行了ＨＬＡ－Ａ、Ｂ位点的抗原检测，计算各抗原的出现频率、基因频率和相对风险值。所获结果与７８例贵州籍汉族健康人（对照组）比较，发现患者中ＨＬＡ－Ｂ２７的相对风险值高达８．２５，Ａ３１、Ａ２８、Ｂ１２、Ａ３３分别为２．６８、２．５７、２．５７和２．２７，说明以上抗原的存在可能与患者的遗传易感性呈正关联；Ａ９、Ｂ６０、Ａ２４、Ｂ２２、Ｂ５１、Ｂ１５、Ｂ１６、Ｂ４８、Ｂ４６、Ｂ７、Ａ１１、Ａ２等的相对风险值均小于１，说明以上抗原的存在对变应性鼻炎具有遗传稳定性。其中Ｂ２７和Ａ９的抗原频率与对照组有显著差异。因限于条件，仅做Ａ、Ｂ位点抗原检测。
In order to elucidate whether there are any features of HLA haplotype in perennial allergic rhinitis and the essentials of its genetic background, the antigen specificities of HLA A, B loci in 31 non kindred adult cases of southern Chinese of Han nationality were detected and calculated the antigen frequency, gene frequency and relative risk value of different alleles evaluated by serological methods. The results were compared with 78 healthy adult individuals of Guizhou Han (control group) and revealed that RR (relative risk) of HLA B 27 was as high as 8.25, RR of A 31 (2.68), A 28 (2.57), B 12 (2.57) and A 33 (2.27) were also higher than the control group. It is suggested that the presence of the above mentioned antigens are positively associated with the genetic liability of the patients. The RR of A 9 , B 60 ,A 24 ,B 22 ,B 51 , B 15 , B 16 , B 48 , B 46 , B 7 , A 11 and A 2 were all lower than 1 representing the genetic stability to allergic rhinitis. The antigen frequency of B 27 and A 9 were significantly different from that of the control group.
出处
《中华耳鼻咽喉科杂志》
CSCD
1997年第1期18-20,共3页
Chinese Journal of Otorhinolaryngology
关键词
变应性鼻炎
HLA-A
抗原
Rhinitis, allergic, perennial HLA A antigens HLA B antigens
